High risk of QT interval prolongation and torsades de pointes associated with intravenous quinidine used for treatment of resistant malaria or babesiosis.

نویسندگان

  • Heather A Wroblewski
  • Richard J Kovacs
  • Joanna R Kingery
  • Brian R Overholser
  • James E Tisdale
چکیده

Cardiac toxicity may be associated with drugs used for malaria. Torsades de pointes (TdP) is a well-known adverse effect of quinidine when used for atrial fibrillation. Intravenous quinidine doses for resistant malaria are 2 to 3 times higher than those used for arrhythmias. Among 6 patients receiving quinidine for malaria or babesiosis, 4 developed QT interval prolongation and 2 experienced TdP. Clinicians should be aware that recommended doses of quinidine for malaria carry a high TdP risk.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 56 8  شماره 

صفحات  -

تاریخ انتشار 2012